1 Gene ofAR113 Plays an Important Role in Ameliorating Western Diet-Aggravated Colitis.

Abstract

Western diet is thought to increase susceptibility to inflammatory bowel disease (IBD), and probiotics are a potential therapeutic agent for IBD. This study revealed the effects ofAR113 andAR113Δ1 on a dextran sulfate sodium (DSS)-induced colitis mouse model under the Western diet (WD). After four weeks of WD and low-sugar and low-fat diet (LD) intervention, induction with 3% DSS, and intragastric administration of probiotics, we found thatAR113 could regulate blood glucose and lipid levels and have a certain protective effect on hepatocytes. Our results suggested that theAR113 alleviated DSS-induced colitis under the Western diet by improving dyslipidemia, repairing intestinal barrier dysfunction, and inhibiting the TLR4/Myd88/TRAF-6/NF-κB inflammatory pathway. However, these changes were not demonstrated in theAR113Δ1, and therefore, we reasoned that the presence of1 may play a crucial role in theAR113 exerting its anti-inflammatory function. The relationship between bile salt hydrolase (BSH) and colitis was worthy of further exploration.