Peer-reviewed veterinary case report
1-Hydroxy-2-pyridinone-based MMP inhibitors: synthesis and biological evaluation for the treatment of ischemic stroke.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2008
- Authors:
- Zhang, Yue-Mei et al.
- Affiliation:
- East Coast Research and Early Development · United States
Abstract
Matrix metalloproteinase-9 (MMP-9) has been implicated in the breakdown of the blood-brain barrier during cerebral ischemia. As a result, inhibition of MMP-9 may have utility as a therapeutic intervention in stroke. Towards this end, we have synthesized a series of 1-hydroxy-2-pyridinones that have excellent in vitro potency in inhibiting MMP-9 in addition to MMP-2. Representative compounds also demonstrate good efficacy in the mouse transient mid-cerebral artery occlusion (tMCAO) model of cerebral ischemia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17981034/