Peer-reviewed veterinary case report
14-3-3σ protein linked to shorter survival in dog kidney cancer
By Suárez-Bonnet, Alejandro et al.·Published in Veterinary pathology·2018·1 Department of Pathobiology and Population Sciences, United Kingdom·View original on PubMed →
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Original publication title: 14-3-3σ Protein Expression in Canine Renal Cell Carcinomas.
- Species:
- dog
Plain-English summary
A study found that 14-3-3 protein expression in kidney tumors of dogs may indicate a worse outcome. In 40 dogs with renal cell carcinomas (kidney cancer), 15 dogs showed abnormal levels of this protein, and these dogs had a significantly shorter survival time. The research suggests that most of these tumors likely develop from a specific part of the kidney. This protein could be a potential target for future treatments, but more research is needed to understand its role in kidney cancer in dogs.
People also search for: dog kidney cancer symptoms · renal cell carcinoma in dogs · 14-3-3 protein treatment for dogs
Abstract
14-3-3σ is a protein expressed in many epithelial tissues associated with essential cell functions, including cell-cycle control, apoptosis, and cytoskeletal integrity. There is a paucity of knowledge of the tumorigenesis of canine renal cell carcinomas (RCCs), and the histological origin of this tumor has not been established. This study analyzed the expression of 14-3-3σ, Ki-67, cytokeratins, and vimentin in 40 canine RCCs. Aberrant expression of 14-3-3σ was demonstrated in 15 (38%) cases and was associated with a significantly shorter survival time ( P < .002). In contrast to canine RCC, normal kidney did not express 14-3-3σ. The Ki-67 proliferation index did not show utility as a prognostic factor. The distal convoluted tubular epithelium in normal kidneys coexpressed cytokeratins and vimentin, and thus maintenance of this coexpression pattern in canine RCC suggests that most tumors arise from the distal segment of the nephron. These results suggest that 14-3-3σ is a potential negative prognostic factor and a possible therapeutic target.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29145797/