Peer-reviewed veterinary case report
17beta-estradiol stimulates proliferation of spermatogonia in experimental cryptorchid mice.
- Journal:
- Asian journal of andrology
- Year:
- 2007
- Authors:
- Li, En-Zhong et al.
- Affiliation:
- Beijing Institute of Basic Medical Sciences · China
- Species:
- rodent
Abstract
AIM: To investigate whether estrogen stimulates the proliferation of spermatogonia or induces spermatogenesis in cryptorchid mice. METHODS: Mice were surgically rendered cryptorchid, then treated with different doses of 17beta-estradiol (E2) s.c. once a day. Mice were killed at sexual maturity (45 days of age), and histological analysis and immunofluorescence were performed. Serum follicle stimulating hormone (FSH), estradiol, testosterone and luteinizing hormone (LH) were measured. RESULTS: Low doses of E2 had no notable effect on spermatogonia, but at higher doses, E2 stimulated the proliferation of spermatogonia. CONCLUSION: E2 has a dose-related mitogenic effect on spermatogonia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17712483/