Peer-reviewed veterinary case report
Dog with urinary blockage from rare 2,8-dihydroxyadenine bladder
By Houston, Doreen M et al.·Published in Journal of the American Veterinary Medical Association·2012·Royal Canin Canada, Canada·View original on PubMed →
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Original publication title: 2,8-Dihydroxyadenine uroliths in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old mixed-breed dog weighing 95 pounds was brought to the vet with difficulty urinating for two days. X-rays and ultrasounds showed swelling in the kidney and ureter, along with unusual stones in the bladder and kidney. After surgery to remove the stones, they were found to be made of a rare substance called 2,8-dihydroxyadenine, rather than the more common urate. The vet prescribed allopurinol, a medication to help manage the condition, and recommended a special diet low in purines to prevent future stones.
People also search for: dog difficulty urinating · 2 · 8-dihydroxyadenine stones in dogs · dog urinary stones treatment
Abstract
CASE DESCRIPTION: A 43-kg (95-lb) 4-year-old neutered male mixed-breed dog was evaluated because of a 2-day history of dysuria. CLINICAL FINDINGS: Radiography and ultrasonography revealed hydronephrosis, hydroureter, and radiolucent, hyperechoic uroliths in the right kidney and ureter and the urinary bladder. Serum bile acids concentration was within the reference interval. TREATMENT AND OUTCOME: The uroliths in the bladder and right ureter were surgically removed and submitted for analysis. They were initially identified as urate uroliths; however, results of further analysis indicated uroliths were composed of 2,8-dihydroxyadenine (2,8-DHA), and 2,8-DHA was identified in a urine sample of the dog. Allopurinol was prescribed for the dog, and a purine-restricted diet was recommended. CLINICAL RELEVANCE: 2,8-DHA uroliths are extremely rare in humans and dogs. Such uroliths may be underdiagnosed in humans because of variability of clinical signs and difficulty in differentiating 2,8-DHA and urate uroliths and crystalluria. Uroliths composed of 2,8-DHA may be misdiagnosed as urate uroliths in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23113528/