Peer-reviewed veterinary case report
4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2006
- Authors:
- Narender, Tadigoppula et al.
- Affiliation:
- Central Drug Research Institute · India
- Species:
- rodent
Abstract
Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by 22% (P<0.02), and free fatty acids by 14%, accompanied by an increase in HDL-C/TC ratio by 39% in the dyslipidemic hamster model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16246556/