Peer-reviewed veterinary case report
41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faRat Model.
- Journal:
- Toxicologic pathology
- Year:
- 2018
- Authors:
- Homer, Bruce L & Dower, Ken
- Affiliation:
- 1 Drug Safety · United States
- Species:
- rodent
Abstract
This symposium synopsis summarizes key results from a 41-week study of diabetic nephropathy (DN) in the type 2 diabetic ZSF1 fa/farat model. During this study, we conducted longitudinal analysis of biomarkers, renal histopathology, ultrastructural assessment, renal quantitative image analysis, and transcriptome analysis of glomerular-enriched tissue. We concluded that there is translational value for using the ZSF1 rat model in mechanistic and therapeutic intervention efficacy studies for type 2 DN.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30278832/