Peer-reviewed veterinary case report
Dog with severe bone marrow failure after 5-fluorouracil poisoning
By Fry, Michael M & Forman, Marnin A·Published in Veterinary and human toxicology·2004·Department of Pathology, United States·View original on PubMed →
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Original publication title: 5-fluorouracil toxicity with severe bone marrow suppression in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old dog showed signs of neurological issues and gastrointestinal problems after being exposed to a toxic medication called 5-fluorouracil (5-FU). This exposure led to severe bone marrow suppression, which means the dog's body wasn't making enough blood cells. After receiving intensive supportive care, the dog recovered within 25 days. This case highlights the serious effects of 5-FU toxicity in dogs and the importance of prompt treatment.
People also search for: dog 5-fluorouracil toxicity · dog bone marrow suppression symptoms · dog recovery from medication poisoning
Abstract
This report describes 5-fluorouracil (5-FU) toxicity in a dog that resulted in severe bone marrow suppression. The dog initially was presented with neurologic and gastrointestinal signs and developed pancytopenia characterized by severe neutropenia and thrombocytopenia. Examination of bone marrow aspirate showed aplasia. The dog also had marked echinocytosis, which has been previously associated with in vitro 5-FU exposure. The patient was given aggressive supportive care and recovered within 25 d of exposure. To the authors' knowledge, this is the first report of a case of 5-FU toxicity in a dog to include results of bone marrow examination, as well as the first to describe echinocytosis related to 5-FU toxicity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15303385/