Peer-reviewed veterinary case report
Common TP53 gene mutation found in dogs with histiocytic sarcoma
By Asada, Hajime et al.·Published in The Journal of veterinary medical science·2017·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma.
- Species:
- dog
Plain-English summary
A study found that nearly half of the dogs with histiocytic sarcoma (a type of cancer) had a specific mutation in the TP53 gene, which is linked to poor outcomes. This mutation was identified in 12 out of 26 dogs, with most of them sharing the same 2-base insertion in the gene. Histiocytic sarcoma is known for being difficult to treat and having a short survival time, so understanding these genetic changes could help in future treatments. More research is needed to see how this mutation affects the disease and treatment options.
People also search for: dog histiocytic sarcoma treatment · TP53 gene mutation in dogs · canine cancer prognosis
Abstract
Canine histiocytic sarcoma (HS) is a malignancy originating from the histiocytic cell lineage and characterized by poor response to chemotherapy and short survival time. Mutation of the TP53 gene and its association with poor prognosis has been reported in several canine tumors. However, the mutation of this gene has not been investigated in canine HS. The aim of this study was to examine a TP53 gene mutation in dogs with HS. Aberrations of the TP53 gene were examined by polymerase chain reaction-single strand conformational polymorphism analysis and DNA sequence analysis, revealing mutations of the TP53 gene in 12 (46%) of 26 dogs affected by HS. The incidence of the TP53 gene mutation was relatively high in canine HS compared with other canine tumors. Among these mutations, 10 of 12 dogs (83%) with a TP53 gene mutation harbored the same mutation: a 2-base (AT) insertion in exon 5, resulting in the introduction of a stop codon (c.446_447insAT, p.Tyr150SerfsX8). Further studies are needed to examine the functional change due to the mutation and its association with the pathogenesis of canine HS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28867679/