Peer-reviewed veterinary case report
Dog with chronic itching treated with new antibody drug over 3 years
By Petrou P.·Published in Folia Veterinaria·2022·Heath and Reach Veterinary Surgery, Kingswood Farm, Brickhill Road, Heath and Reach, Leighton Buzzard, LU7 0BA, United Kingdom, PL·View original on DOAJ →
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Original publication title: A 3-Year Case Report on an Atopic Patient with a Caninised Monoclonal Antibody Treatment
- Species:
- dog
Plain-English summary
A 6-year-old male English Mastiff was brought in for a second opinion due to ongoing itching that had lasted for four years. Despite being treated with medications like methylprednisolone and chlorphenamine, the dog still suffered from severe skin problems caused by canine atopic dermatitis (a common allergic skin condition). After thorough testing, the vet started the dog on a new treatment called lokivetmab, a specialized antibody therapy. This treatment, along with occasional use of other medications during flare-ups, significantly improved the dog's condition over the three years of treatment.
People also search for: English Mastiff itching treatment · dog atopic dermatitis medication · lokivetmab for dogs
Abstract
A 6-year-old, male, neutered, English Mastiff dog was presented for a second opinion due to chronic pruritus. The patient had been on methylprednisolone and chlorphenamine for four years. The diagnostic investigations included: swabs for bacterial and mycology culture, hair plugs for dermatophyte culture, acetate tape strips and deep skin scrapes, skin biopsies for dermatohistopathology, biochemistry, haematology, endocrinology, serology for canine scabies using enzyme-linked immunosorbent assay (ELISA) testing and serology for allergen specific IgE antibodies. The history and the diagnostics confirmed the diagnosis of canine atopic dermatitis. This case report details the treatment with lokivetmab, which is a caninised monoclonal antibody drug. At periods of flare ups, additional treatments were prescribed, such as systemic glucocorticoids and oclacitinib in order to manage the clinical signs. The treatment showed good response to the overall treatment management during the three year period of this atopic patient.
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Search related cases →Original publication on DOAJ: https://doi.org/10.2478/fv-2022-0005