Peer-reviewed veterinary case report
A 6-hydroxydopamine in vivo model of Parkinson's disease.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2012
- Authors:
- Mercanti, Giulia et al.
- Affiliation:
- Department of Pharmacology and Anesthesiology · Italy
- Species:
- rodent
Abstract
Animal models of Parkinson's disease are essential to explore pathophysiological hypotheses and to test new treatment options, including neurotrophic factors. Catecholaminergic neurotoxins used to generate such models are 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These neurotoxins predominantly kill dopaminergic neurons through oxidative damage and mitochondrial failure, although 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine fails to induce a significant dopaminergic neurodegeneration in rats. The present chapter describes a protocol for the 6-hydroxydopamine rat model based on stereotaxic injection performed only unilaterally, which mimics an early-to-mid stage of the disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22367825/