Peer-reviewed veterinary case report
Dog kidney tumor with gum spread in Miniature Pinscher case
By Chen, Bo et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·Graduate Institute of Molecular and Comparative Pathobiology·View original on PubMed →
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Original publication title: A blastema-predominant canine renal nephroblastoma with gingival metastasis: case report and literature review.
- Species:
- dog
Plain-English summary
An 8-year-old Miniature Pinscher was diagnosed with a rare kidney tumor called nephroblastoma, which had spread to the gums. The dog showed signs of illness, and after testing, the tumor was found to be aggressive, classified as stage IV, meaning it had advanced significantly. Unfortunately, the prognosis was poor, with an expected survival time of less than four months. This case highlights the seriousness of kidney tumors in dogs and the importance of early detection and treatment.
People also search for: Miniature Pinscher kidney tumor · dog gingival mass · nephroblastoma in dogs treatment
Abstract
Nephroblastomas are uncommon embryonal tumors in dogs. We report herein a blastema-predominant nephroblastoma with gingival metastasis in an 8-y-old Miniature Pinscher dog. Histologically, the mass was composed mainly of blastemal elements with minor epithelial and mesenchymal differentiation. Metastatic masses in the gingiva had histologic and immunohistochemical features similar to those of the primary renal nephroblastoma. Neoplastic cells were extensively positive for both vimentin and PAX8, and scattered positive for cytokeratin. Using the clinical staging of human Wilms tumor, we staged our case as stage IV with <4 mo of survival time. We summarized previous studies of canine renal and spinal nephroblastomas, and analyzed the correlations among clinical staging, histologic classification, and mean survival time of dogs with renal nephroblastomas. Clinical staging was significantly correlated with survival time, as shown in humans. In dogs, however, additional factors can potentially influence the outcome of treatment and disease development.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29528810/