Peer-reviewed veterinary case report
Long-term safety and effect of enflicoxib for dog osteoarthritis
By Homedes, Josep et al.·Published in Frontiers in veterinary science·2024·Ecuphar Veterinaria SLU (Animalcare Group) Sant Cugat del Vallè, Spain·View original on PubMed →
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Original publication title: A blinded, randomized and controlled multicenter field study investigating the safety and efficacy of long-term use of enflicoxib in the treatment of naturally occurring osteoarthritis in client-owned dogs.
- Species:
- dog
Plain-English summary
A group of 109 dogs with osteoarthritis (OA) received either enflicoxib, a pain relief medication, or a placebo for six months to see how well it worked for their joint pain. The dogs taking enflicoxib showed significant improvement in their pain levels and mobility compared to those on the placebo, with about 72% of the enflicoxib group reporting better results. Throughout the study, the medication was found to be safe, with no serious side effects noted. This suggests that enflicoxib is a good option for long-term management of OA in dogs.
People also search for: dog osteoarthritis treatment · enflicoxib for dogs · dog joint pain relief options
Abstract
BACKGROUND: Enflicoxib is a COX-2 selective NSAID shown to be efficacious and safe in the treatment of pain and inflammation associated with canine osteoarthritis (OA) in clinical studies of 6 weeks duration. OBJECTIVE: This prospective, multisite, blinded, randomized, placebo-controlled, parallel-group field study aimed to confirm the safety and efficacy of enflicoxib in long-term canine OA treatments. ANIMALS: A total of 109 client owned dogs with clinical and radiographic signs of OA for at least 3 weeks were enrolled with 78 dogs completing all study visits. METHODS: Dogs were randomized at a 3:1 ratio to receive enflicoxib (= 83) or placebo (= 26) once weekly during 6 months. Dogs underwent veterinary assessments from Day 0 to Day 189 using a clinical sum score (CSS). Efficacy was also assessed by the owners using the Canine Brief Pain Inventory (CBPI). Safety was assessed clinically and by repeated blood and urine sample analysis. The efficacy outcome measure was the treatment response according to the CSS and secondarily the treatment response according to the CBPI. The primary safety outcome was the incidence of adverse events (AEs) and secondarily the evolution of the clinical pathology parameters. RESULTS: Percentages of CSS responders for enflicoxib were 71.6; 74.6 and 71.6% on Days 44, 135 and 189 respectively, always showing statistically significant differences (< 0.05) vs. placebo (41.7, 33.3, and 20.8% respectively). Treatment response according to owner assessments followed the same pattern, achieving significant differences compared to placebo after 2 weeks of treatment. The incidence and type of AEs were as described in previous enflicoxib studies of shorter duration and as for other NSAIDs, with no tendency to increase over time. No relevant changes in hematology, biochemistry or urine parameters were observed. CONCLUSIONS AND CLINICAL RELEVANCE: Enflicoxib safety and efficacy profile is maintained after a long-term treatment, which together with its weekly administration, makes it a good alternative for the chronic treatment of dogs with naturally occurring OA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38585299/