Peer-reviewed veterinary case report
Shetland sheepdog diagnosed with discoid lupus and autoantibodies
By Iwasaki, T et al.·Published in The Journal of veterinary medical science·1995·Department of Pathology, Japan·View original on PubMed →
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Original publication title: A canine case of discoid lupus erythematosus with circulating autoantibody.
- Species:
- dog
Plain-English summary
A 9-year-old Shetland sheepdog was diagnosed with discoid lupus erythematosus, a skin condition that can cause sores and lesions, particularly on the nose and face. The diagnosis was confirmed through skin tests and the presence of specific autoantibodies. While the dog did not show signs of other systemic diseases, the condition can be serious if not managed properly. Treatment options typically include medications to reduce inflammation and manage symptoms.
People also search for: Shetland sheepdog skin problems · discoid lupus in dogs treatment · dog autoimmune skin disease
Abstract
A nine-year-old Shetland sheepdog was diagnosed as discoid lupus erythematosus by clinical features, histopathologic findings, positive direct immunofluorescence, negative antinuclear antigen test and the absence of multisystemic diseases. The indirect immunofluorescence test of this patient dog with the salt split skin showed the deposition at the bottom of the cleft at basement membrane zone (BMZ). Western immunoblotting revealed the 120 kDa and the 85 kDa proteins targeted by the autoantibody. These proteins did not correspond with the known BMZ component.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8720056/