Peer-reviewed veterinary case report
Dog with pemphigus foliaceus skin disease tracked by antibody levels
By Nishifuji, Koji et al.·Published in The Journal of veterinary medical science·2005·Department of Dermatology, Japan·View original on PubMed →
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Original publication title: A canine pemphigus foliaceus case showing parallel relationship of disease activity and titer of serum anti-keratinocyte cell surface antibodies.
- Species:
- dog
Plain-English summary
A 7-year-old spayed female mongrel dog was diagnosed with pemphigus foliaceus, a skin condition that causes painful blisters and sores. The vet used special tests to detect antibodies in the dog's blood that attack her skin cells. By monitoring these antibody levels over time, the vet could track how active the disease was. This approach may help vets better manage and treat dogs with this condition in the future.
People also search for: dog skin blisters treatment · pemphigus foliaceus in dogs · dog autoimmune skin disease symptoms
Abstract
A seven-year-old, spayed female mongrel dog was diagnosed as pemphigus foliaceus (PF) by clinical, histopathological and immunopathological observations. Serum antibodies against the cell surface of keratinocytes in the dog were detected by indirect immunofluorescence (IIF) using cryosectioned bovine esophagus as well as living cultured-canine keratinocytes as the substrates. When we compared the titers of IIF on bovine esophagus with its disease activity, the IIF titers reflected the disease activity throughout the time course. Our findings will suggest that sequential titration of serum antibodies by IIF will be useful for monitoring the serological disease activity in canine PF.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16210809/