Peer-reviewed veterinary case report
New antibody treatment reduces joint pain and improves movement
By Lascelles, B Duncan X et al.·Published in BMC veterinary research·2015·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain.
- Species:
- dog
Plain-English summary
A group of 26 dogs with degenerative joint disease (DJD) pain received either a new treatment called NV-01 or a placebo to see if it could help reduce their pain and improve their mobility. The dogs treated with NV-01 showed significant improvements in pain levels and activity over 28 days, while those on the placebo did not experience the same benefits. Owners reported that their dogs were moving better and seemed more comfortable without any side effects from the treatment. This new anti-nerve growth factor antibody could be a promising option for managing chronic pain in dogs.
People also search for: dog joint pain treatment · NV-01 for dogs arthritis · how to help dog with degenerative joint disease
Abstract
BACKGROUND: There is a critical need for proven drugs other than non-steroidal anti-inflammatory drugs for treatment of degenerative joint disease (DJD) pain in dogs. Antibodies against nerve growth factor (NGF) are analgesic in rodent models and in humans with DJD. This pilot study aimed to evaluate the efficacy of a novel caninised anti-NGF antibody (NV-01) for the treatment of DJD pain in dogs. In a randomized, parallel group, stratified, double masked, placebo controlled, proof of principle clinical pilot study design, 26 dogs with DJD received NV-01 (200 mcg/kg IV) or placebo on day 0 (D0). In addition to objective accelerometry measures, owners completed clinical metrology instruments (Client-Specific Outcome Measures [CSOM], Canine Brief Pain Inventory [CBPI] and Liverpool Osteoarthritis in Dogs Index [LOAD]) on D0, D14 and D28. CBPI subscales (pain severity [PS] and pain interference [PI]), CSOM and LOAD scores were evaluated within and between groups for change over time. Recognized success/failure criteria were applied and success compared between groups. RESULTS: CBPI PS and PI scores significantly improved in the NV-01 group (PS: D0-14, P = 0.012 and D0-28, P = 0.019; PI: D0-14, P = 0.012 and D0-28, P = 0.032) but not in the placebo group. CSOM scores showed similar patterns with a significant difference between within-group changes at D14 and D28 (P = 0.038 and P = 0.009, respectively), and significantly more successes at D28 (P = 0.047). LOAD scores significantly improved in the NV-01 group (D0-14, P = 0.004 and D0-28, P = 0.002) but not in the placebo group. There were significant differences between the groups for change in LOAD score at D14 (P = 0.014) and D28 (P = 0.033). No side effects were noted. Activity in the NV-01 group increased over the study period compared to placebo (P = 0.063) and the difference between the groups for change in activity over the time period 9am-5pm (8 hours) was significant (P = 0.006). CONCLUSIONS: These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain. The magnitude of the effect appeared identical to that expected with an NSAID.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25926287/