Peer-reviewed veterinary case report
Dog vaccine for Leptospira protects against multiple serovars
By Bouvet, J et al.·Published in Veterinary immunology and immunopathology·2020·Boehringer Ingelheim Animal Health, France·View original on PubMed →
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Original publication title: A canine vaccine against Leptospira serovars Icterohaemorrhagiae, Canicola and Grippotyphosa provides cross protection against Leptospira serovar Copenhageni.
- Species:
- dog
Plain-English summary
A study showed that a vaccine for dogs can protect against leptospirosis, a serious disease caused by bacteria. After getting the DAPPi-L vaccine, dogs were found to have protection not only against the main strains it targets but also against a dangerous strain called Copenhageni. This means that vaccinated dogs were less likely to show symptoms, suffer from kidney infections, or even die from the disease. The vaccine was effective just two weeks after the initial vaccination, making it a valuable option for preventing leptospirosis in dogs.
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Abstract
Efficacy of the Leptospira components of multivalent vaccine DAPPi-L was previously demonstrated against virulent challenge with three serovars of Leptospira interrogans (Canicola, Icterohaemorrhagiae and Grippotyphosa) carried out 14 days after primary vaccination. In this study we demonstrate that this vaccine provides, two weeks after vaccination, an additional protection (prevention of mortality, clinical signs, renal infection, bacterial excretion, renal carriage and renal lesions) against fatal leptospirosis due to Leptospira interrogans serovar Copenhageni (serovar of major medical importance).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31759261/