Peer-reviewed veterinary case report
Golden Retriever with oral mass and bone loss from lymphoma
By Ito, Tetsuro et al.·Published in The Journal of veterinary medical science·2007·Veterinary Teaching Hospital, Japan·View original on PubMed →
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Original publication title: A case of atypical canine lymphoma with oral mass and multiple osteolysis.
- Species:
- dog
Plain-English summary
An 8-year-old female Golden Retriever was brought in with an oral mass and limping due to bone pain. Tests showed unusual cells in her mouth and bone marrow, leading to a diagnosis of atypical lymphoma, a type of cancer. She was treated with a combination of chemotherapy drugs. By day 142 after starting treatment, her condition improved significantly, with the oral mass shrinking and her bone pain resolving.
People also search for: Golden Retriever oral mass · dog limping cancer treatment · atypical lymphoma chemotherapy for dogs
Abstract
An 8-year-old female Golden Retriever had an oral mass and lameness. Multiple osteolysis of the systemic skeleton without monoclonal gammopathy was shown on electrophoresis of serum and urine samples. Cytological and histopathological examinations of the oral mass revealed atypical polymorphic cells similar to myeloid cells, and bone marrow aspiration indicated that these abnormal cells also might have invaded the bone marrow. These cells were negative to peroxidase and non-specific esterase staining, and clonal expansion of B lymphocytes could be detected by polymerase chain reaction (PCR) assay for antigen receptor gene rearrangement. The case was diagnosed as atypical lymphoma and treated by multi-drug chemotherapy. On the 142nd day after the first admission, the case had remission and the oral mass and multiple osteolysis were improved.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17917387/