Peer-reviewed veterinary case report
A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration.
- Journal:
- Veterinary medicine and science
- Year:
- 2021
- Authors:
- Akiyoshi, Makoto & Akiyoshi, Masami
- Affiliation:
- Akiyoshi Animal Clinic · Japan
- Species:
- cat
Plain-English summary
A 7-year-old spayed female Scottish Fold cat had been not eating, losing weight, and vomiting for about four weeks. An ultrasound of her abdomen showed a mass in her intestine and a slightly swollen lymph node nearby. A sample taken from the mass showed it was a type of cancer called large granular lymphocyte lymphoma. The mass was completely removed through surgery, and follow-up tests showed no signs of cancer in other organs. After surgery, she received chemotherapy with nimustine, and she has been doing well with no side effects, continuing treatment every six weeks for over a year. The cat is currently in good health, and the cancer has not come back.
Abstract
A 7-year-old spayed female Scottish Fold cat presented with a 4-week history of anorexia, weight loss and vomiting. Abdominal ultrasonography revealed a jejunal mass and a slightly enlarged jejunal lymph node. A fine-needle aspiration of the mass revealed many round cells with multiple small intracytoplasmic magenta granules. The mass was diagnosed as a large granular lymphocyte (LGL) lymphoma based on cytology. The LGL lymphoma was completely resected via open surgery. The histologic and cytologic evaluations showed no neoplastic findings in the jejunal lymph node, liver, spleen, kidney or bone marrow. The LGL lymphoma was localized to the jejunum. Postoperatively, the cat received chemotherapy with nimustine, L-asparaginase and prednisolone. The cat is currently receiving nimustine every 6 weeks, without adverse events, and treatment has been administrated a total of 18 times up until day 552. The cat is in a good condition, and the LGL lymphoma has not recurred. Nimustine should be considered one of the effective chemotherapeutic agents in the treatment of feline LGL lymphoma cases in the future.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34405564/