Peer-reviewed veterinary case report
Cat with temporal lobe epilepsy linked to hippocampus malformation
By Chambers, James K et al.·Published in The Journal of veterinary medical science·2022·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation.
- Species:
- cat
Plain-English summary
A 2-month-old male mixed breed cat was brought in for frequent seizures. Despite treatment, the cat suffered from drug-resistant epilepsy and sadly passed away at 3 years old. A post-mortem examination revealed no obvious lesions, but tests showed significant changes in the brain, indicating severe neuronal loss and malformations. This case highlights the challenges of managing epilepsy in cats, especially when it is linked to structural brain issues.
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Abstract
A two-months-old, male, mixed breed cat presented with epileptic seizures. The cat was diagnosed with drug-resistant epilepsy, and died at 3-years of age. No gross lesion was found at necropsy. Histopathologically, the dentate gyrus granule cell layer of the hippocampus was irregularly arranged. Granule cells were dispersed and ectopic cells were sporadically observed in the molecular layer. The granule cells had an enlarged cytoplasm and swollen nucleus. Immunohistochemistry for NeuN and GFAP confirmed severe neuronal loss and mild gliosis in CA1. Binucleation and ischemic change were observed in the remaining pyramidal cells. This report describes a case of feline temporal lobe epilepsy and hippocampal sclerosis associated with dentate gyrus malformation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35342145/