Peer-reviewed veterinary case report
Protein-losing enteropathy with diarrhea treated by methotrexate
By Yuki, Masashi et al.·Published in The Journal of veterinary medical science·2006·Yuki Animal Hospital, Japan·View original on PubMed →
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Original publication title: A case of protein-losing enteropathy treated with methotrexate in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old female Pug was brought in for chronic diarrhea and was found to have low protein levels in her blood. After an examination, the vet diagnosed her with protein-losing enteropathy, a condition where the intestines leak protein due to inflammation. The initial treatments with prednisolone and cyclosporine didn't help, but when methotrexate was used instead of cyclosporine, the dog's condition improved. This change in medication helped confirm the diagnosis and led to better management of her symptoms.
People also search for: dog chronic diarrhea treatment · Pug protein-losing enteropathy · methotrexate for dogs diarrhea
Abstract
A 9-year-old female Pug was presented to us with chronic diarrhea. Hematologic findings indicated severe hypoproteinemia and hypoalbuminemia, and endoscopy revealed severe edema of the duodenal mucosa. Based on these results and on additional histopathological findings, we made a diagnosis of protein-losing enteropathy caused by lymphocytic-plasmacytic enteritis with lymphangiectasia. The dog was initially treated with prednisolone and cyclosporine. This treatment regimen was not effective. However, when methotrexate was substituted for cyclosporine, progress was obtained and the diagnosis was confirmed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16679735/