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Peer-reviewed veterinary case report

Rapid kidney tumor spread in young German shepherd dog after surgery

By Seddon, Kathleen et al.·Published in Veterinary Record Case Reports·2023·The Animal Referral Centre Auckland New Zealand·View original on Crossref

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Original publication title: A case of rapid canine nephroblastoma presumed metastasis documented with advanced imaging

Species:
dog

Plain-English summary

A 1.5-year-old female German shepherd was brought in because of a large abdominal mass and symptoms like excessive thirst, frequent urination, diarrhea, and weight loss despite eating well. An ultrasound showed a big mass around her uterus and kidney, and surgery confirmed it was a type of kidney cancer called nephroblastoma. Unfortunately, the owner chose not to pursue chemotherapy, and just over two months after surgery, scans revealed that the cancer had spread significantly. Sadly, the dog was euthanized about four months after her surgery due to worsening health.

People also search for: German shepherd abdominal mass · dog weight loss and increased thirst · nephroblastoma in dogs treatment options

Abstract

Abstract A 1.5‐year‐old, female, entire German shepherd dog was presented for evaluation of an abdominal mass. The dog had a 4‐month history of polydipsia, polyuria, diarrhoea, and weight loss despite polyphagia. Abdominal ultrasound confirmed a large abdominal mass suspected to be uterine in origin. An exploratory celiotomy revealed a 4.3 kg, 26 × 17 × 17 cm multinodular mass entirely encompassing the uterus, left ovary and left kidney. A combined ovariohysterectomy and left nephrectomy were undertaken. Histopathology confirmed stage ΙΙ renal nephroblastoma with favourable histology. Chemotherapy was declined and 86 days following surgery, significant abdominal metastases were identified on a computed tomography scan. The patient was euthanased 113 days after surgery due to progressive disease. This is the first report to display the rapid presumed metastasis of a canine nephroblastoma, without gross metastasis at initial surgical resection, through advanced imaging. This is also the first reported case of polyphagia despite weight loss as a presenting clinical sign.

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Original publication on Crossref: https://doi.org/10.1002/vrc2.560