Peer-reviewed veterinary case report
Border collie with skin lupus healed by tacrolimus and antibiotics
By Lehner, Georg M & Linek, Monika·Published in Veterinary dermatology·2013·Tierä, Germany·View original on PubMed →
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Original publication title: A case of vesicular cutaneous lupus erythematosus in a Border collie successfully treated with topical tacrolimus and nicotinamide-tetracycline.
- Species:
- dog
Plain-English summary
An 8-year-old male neutered Border collie was brought in with painful sores on his belly, groin, and around his mouth. The vet diagnosed him with vesicular cutaneous lupus erythematosus, an autoimmune skin condition. To treat it, the vet used a topical medication called tacrolimus along with nicotinamide and tetracycline. After about 2.5 months of treatment, the dog was completely healed and remained free of lesions for a year afterward.
People also search for: Border collie skin sores treatment · lupus in dogs · tacrolimus for dog skin problems
Abstract
BACKGROUND: Canine vesicular cutaneous lupus erythematosus (VCLE) is an autoimmune skin disease of the Shetland sheepdog and rough collie, which manifests as an erosive dermatitis of sparsely haired skin of the ventrum and concave pinnae. Reported treatment consists of immunosuppression with glucocorticoids alone or in combination with azathioprine, but successful treatment is unpredictable. OBJECTIVES: To report on the treatment of VCLE in a Border collie dog with topical 0.1% tacrolimus and nicotinamide in combination with tetracycline. CASE REPORT: An 8-year-old male neutered Border collie was presented with multiple coalescing erosions on the ventral abdomen, groin and axillae and ulceration on the oral commissures. Clinical presentation, routine diagnostics, histology and immunohistochemistry were consistent with VCLE. Remission was achieved with topical 0.1% tacrolimus and combination therapy of nicotinamide and tetracycline. CONCLUSION AND CLINICAL IMPORTANCE: This dog responded well to treatment with topical 0.1% tacrolimus, nicotinamide-tetracycline and sun avoidance. Complete remission was achieved after 2.5 months, and the dog was lesion free during a 1 year follow-up period.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24118370/