Peer-reviewed veterinary case report
Beagle dog with diabetes and paw skin sores explained
By Yoshida, M et al.·Published in Toxicologic pathology·1996·Department of Pathology, Japan·View original on PubMed →
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Original publication title: A case report of superficial necrolytic dermatitis in a beagle dog with diabetes mellitus.
- Species:
- dog
Plain-English summary
A young beagle with diabetes was brought in for skin problems, specifically swelling and sores between its toes. The vet found that the dog's diabetes was causing changes in its skin and other organs, leading to a condition called superficial necrolytic dermatitis. Blood tests showed high glucose and glucagon levels, which contributed to the skin issues. Treatment focused on managing the diabetes, which is essential for improving the skin condition. With proper care, the dog's symptoms can be managed effectively.
People also search for: beagle skin problems · dog diabetes treatment · superficial necrolytic dermatitis in dogs
Abstract
A case of superficial necrolytic dermatitis in a young laboratory beagle dog with diabetes mellitus was investigated. Macroscopically, the skin lesion was restricted to paws showing erosion and swelling of the interdigital areas. The most predominant histopathological feature was upper-epidermal vacuolation of keratinocytes. In the pancreas, the number and size of islets were found to be markedly reduced, and only glucagon-positive cells were detected. In the liver, severe and widespread vacuolation of hepatocytes was observed. Blood biochemical assays showed that the serum glucose and plasma glucagon levels were increased. In addition, levels of individual amino acids varied markedly, although the total amino acid concentration was within the normal range. From these results, it was suggested that the skin lesion in this case was primarily caused by hyperglucagonemia in diabetes mellitus.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8864192/