Peer-reviewed veterinary case report
Cat with myelodysplastic syndrome treated with azacytidine
By Hisasue, Masaharu et al.·Published in The Journal of veterinary medical science·2022·Azabu University, Japan·View original on PubMed →
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Original publication title: A cat with myelodysplastic syndrome by administration of the methylation inhibitor Azacytidine.
- Species:
- cat
Plain-English summary
A 5-year-old female cat was brought to the vet because she had low red blood cells and low platelets, which are signs of a serious blood disorder called myelodysplastic syndrome (MDS). The vet treated her with a chemotherapy drug called azacytidine, along with prednisolone, antibiotics, vitamin K2, and blood transfusions. After treatment, the cat showed improvement, with a decrease in abnormal blood cells, and she lived for over four years after the diagnosis. This case highlights the potential effectiveness of azacytidine for treating MDS in cats.
People also search for: cat anemia treatment · myelodysplastic syndrome in cats · azacytidine for cats
Abstract
A 5-year-old female cat with nonregenerative anemia and thrombocytopenia was diagnosed with myelodysplastic syndromes (MDS), since peripheral blood and bone marrow (BM) examination revealed various dysplasias and a blast ratio of 19%. Chemotherapy with azacytidine (AZA; 70-35 mg/m, 3-5 days, three cycles) and treatment with prednisolone, antibiotics, and vitamin K2, and blood transfusion were performed. On day 106, blast cells and dysplasia had decreased in the BM, and the cat remained alive for at least 1,474 days. This report is the first on feline MDS treated with AZA, suggesting appropriate drug dosage, interval and effective combination should be investigated and the pharmacological and cell biological mechanisms needs to be elucidated in the future.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34866071/