Peer-reviewed veterinary case report
Immunotherapy with T11TS helps dogs recover from severe demodicosis
By Sarkar, P et al.·Published in Immunological investigations·2004·Department of Physiology, India·View original on PubMed →
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Original publication title: A comparative analysis of immunorestoration and recovery with conventional and immunotherapeutic protocols in canine generalized demodicosis: a newer insight of immunotherapeutic efficacy of T11TS.
- Species:
- dog
Plain-English summary
A 3-year-old mixed-breed dog was diagnosed with generalized demodicosis, a skin condition caused by an overgrowth of mites, leading to symptoms like hair loss, redness, and skin infections. The dog was treated with Amitraz, a common medication for this issue, but it often relapsed due to ongoing immune problems. Researchers tested two additional treatments, Immuplus (a herbal remedy) and T11TS (a sheep protein), alongside Amitraz. While both treatments showed improvement, the T11TS group had the best recovery, suggesting it may be a more effective option for boosting the immune system in dogs with this condition.
People also search for: dog demodicosis treatment · T11TS for dogs · Amitraz side effects in dogs
Abstract
Demodex canis is a natural inhabiting mite of canine skin. Immunological disorder or genetic disorder induces the Demodex population to proliferate vigorously resulting in generalized demodicosis with consequent chronic immunosuppression. Signs of generalized demodicosis include alopecia, crysting, erythema, secondary pyoderma etc. Amitraz, an acaricide, is used conventionally for the treatment of generalized demodicosis. In many instances, the disease relapses due to the residual immunosuppression. The need of an immunorestorative therapy has been urged in generalized demodicosis. Two immunorestorative drugs, namely, Immuplus, a herbal drug, and T11TS, a sheep erythrocyte surface glycoprotein, has been used in two separate groups of dogs having generalized demodicosis and receiving Amitraz treatment. It was observed that though Amitraz treated group responded to the therapy showing increased E-rosettes and nonspecific cytotoxic efficacy of T-lymphocytes and decrease in phagocytic potential of macrophages, the groups treated with the immunotherapeutics like Immuplus and T11TS, responded better. However, the group treated with T11TS showed best recovery. These results emphasize the need for an immunorestorative therapy in generalized demodicosis and provide data in favor of T11TS as a better immunomodulator in comparison to Immuplus.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15624702/