Peer-reviewed veterinary case report
How fast fipronil-methoprene kills fleas on cats compared
By Franc, M & Beugnet, F·Published in Veterinary therapeutics : research in applied veterinary medicine·2008·UMR181 Physiopathologie et Toxicologie Expé, France·View original on PubMed →
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Original publication title: A comparative evaluation of the speed of kill and duration of efficacy against weekly infestations with fleas on cats treated with fipronil-(S)-methoprene or metaflumizone.
- Species:
- cat
Plain-English summary
A group of adult cats with flea infestations were treated with either a combination of fipronil-(S)-methoprene or metaflumizone to see which worked better at killing fleas quickly and for a longer time. The cats treated with fipronil-(S)-methoprene had significantly fewer fleas within just 12 and 18 hours after treatment, and this effectiveness continued for weeks. In contrast, the metaflumizone treatment was less effective overall. The study suggests that fipronil-(S)-methoprene is a better option for controlling fleas in cats.
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Abstract
Spot-on formulations of metaflumizone and a combination of fipronil-(S)-methoprene were evaluated in adult cats to determine the duration of 24- and 48-hour efficacy and short-term speed of kill against adult cat fleas, Ctenocephalides felis felis. Speed of kill efficacies (at 12, 18, 24, and 48 hours) were assessed against existing (day -1) infestations and against infestations at day 7, and efficacy was assessed 24 and 48 hours after weekly flea infestations through day 42. Cats treated with fipronil-(S)-methoprene had significantly (P<.01) fewer fleas than those treated with metaflumizone at 12 and 18 hours after treatment (day 0) and on the day 7 infestations. Fipronil-(S)-methoprene-treated cats also had significantly (P<.05) fewer fleas than metaflumizone-treated cats for all 24-hour counts from initial treatment on day 0 through infestation day 42 and for the 48-hour counts on day 28 through day 42.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18597248/