Peer-reviewed veterinary case report
A Comparative Study of the Pharmacokinetics of Bis- and Pentaphosphonic Acids Labeled with Gallium-68 in Rats with Experimental Model of Bone Callus.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2020
- Authors:
- Tishchenko, V K et al.
- Affiliation:
- National Medical Research Center of Radiology
- Species:
- rodent
Abstract
We analyzed biodistribution ofGa-labeled hydroxyethylidenediphosphonic acid (Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (Ga-DTPMP) in Wistar rats with experimental model of bone callus. It was shown that the content ofGa-DTPMP andGa-HEDP in bone callus was ~1.5-fold higher than in intact femur.Ga-DTPMP was characterized by higher stability in vivo, higher uptake in the bone tissue, and lower uptake in others visceral organs in comparison withGa-HEDP. Thus,Ga-DTPMP had more suitable pharmacokinetic properties thanGa-HEDP.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32986215/