Peer-reviewed veterinary case report
Maropitant prevents morphine vomiting in dogs better than
By Lorenzutti, Augusto M et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2017·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: A comparison between maropitant and metoclopramide for the prevention of morphine-induced nausea and vomiting in dogs.
- Species:
- dog
Plain-English summary
A group of 63 dogs were given morphine before surgery, which often causes nausea and vomiting. To prevent these symptoms, they received either maropitant, metoclopramide, or a saline solution. The results showed that none of the dogs given maropitant vomited, while 38% of those given metoclopramide and 71% of those given saline did vomit. However, more dogs felt discomfort from the maropitant injection compared to the other treatments. Overall, maropitant was effective in preventing vomiting from morphine, making it a good option for pre-surgery use.
People also search for: dog vomiting after morphine · maropitant for dogs nausea · metoclopramide side effects in dogs
Abstract
Morphine is widely used as a preanesthetic agent in dogs, but it often produces signs of nausea and vomiting. Maropitant (MRP) and metoclopramide (MCP) prevent emesis attributable to the opioid agent apomorphine in dogs. We evaluated the antiemetic efficacy and the discomfort in response to SQ injection of MRP [1 mg/kg body weight (BW)], MCP (0.5 mg/kg BW), and normal saline (SAL; 0.1 mL/kg BW) administered to 63 dogs, 45 minutes prior to morphine (0.5 mg/kg BW) and acepromazine (0.05 mg/kg BW). Dogs were observed for signs of nausea (ptyalism, lip licking, and increased swallowing) and vomiting for 30 minutes after morphine/acepromazine. The incidence of emesis was 0% for MRP, 38% for MCP, and 71% for SAL (< 0.001). The incidence of signs of nausea was not different between groups. Discomfort due to injection was higher after MRP (48%), than after MCP (9.8%) and SAL (4.8%) (< 0.001).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28042152/