Peer-reviewed veterinary case report
Dogs with necrotizing meningoencephalitis live longer
By Jung, Dong-In et al.·Published in The Journal of veterinary medical science·2007·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: A comparison of combination therapy (cyclosporine plus prednisolone) with sole prednisolone therapy in 7 dogs with necrotizing meningoencephalitis.
- Species:
- dog
Plain-English summary
A group of 7 dogs diagnosed with necrotizing meningoencephalitis (a serious brain condition) were treated with either a combination of cyclosporine and prednisolone or just prednisolone alone. The dogs receiving the combination therapy had a significantly longer survival time, averaging about 306 days, compared to just 58 days for those on prednisolone alone. This suggests that using both medications together may be more effective for managing this condition in dogs. If your dog is showing signs of neurological issues, it may be worth discussing this combination treatment with your veterinarian.
People also search for: dog brain disease treatment · necrotizing meningoencephalitis in dogs · cyclosporine for dogs · prednisolone side effects in dogs
Abstract
Administration of immunosuppressive doses of glucocorticosteroids is the traditional primary treatment in necrotizing meningoencephalitis (NME) in dogs. However, response is variable and clinical signs often recur quickly with tapering dosage. Prognosis is poor and long-term therapy causes many complications. In the present study, we compared the long-term effects of combination (cyclosporine plus prednisolone) therapy with sole prednisolone therapy in management in dogs with NME. All NME cases in this study were examined with magnetic resonance imaging and cerebrospinal fluid analysis, and confirmed by histopathologic examination. The mean survival time of combination therapy group was 305.7 +/- 94.7 days. The mean survival time of sole prednisolone therapy group was 58.3 +/- 30.5 days. This case report demonstrates that combination treatment of cyclosporine with prednisolone is more effective in survival time than administration of only prednisolone in NME cases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18176031/