Peer-reviewed veterinary case report
Trilostane once vs twice daily for dogs with Cushing's disease
By Augusto, M et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2012·Anderson Moores Veterinary Specialists, United Kingdom·View original on PubMed →
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Original publication title: A comparison of once and twice daily administration of trilostane to dogs with hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of dogs with Cushing's disease (hyperadrenocorticism) were treated with a medication called trilostane either once or twice a day to see which method worked better. Over six months, both groups showed improvement in their symptoms, but the dogs receiving trilostane twice daily had better control of their cortisol levels more quickly. While the once-daily group tolerated the treatment slightly better, there were no serious side effects in either group. Overall, both dosing schedules were effective, but the twice-daily option may offer quicker results.
People also search for: dog Cushing's disease treatment · trilostane for dogs · twice daily medication for dogs
Abstract
OBJECTIVE: This retrospective study describes the use of trilostane given once versus twice daily in dogs with hyperadrenocorticism (SID vs. BID-group) in separate clinical trials. MATERIAL AND METHODS: The groups were compared over a six month period using laboratory findings, dose required to suppress post-ACTH cortisol, and clinical scores from owner and clinician questionnaires. RESULTS: Ninety-three dogs enrolled the trials but for analysis of the final visit results only 56 dogs filled the inclusion criteria: 30 dogs in the SID-group and 26 dogs in the BID-group. Both treatment groups showed an improvement in clinical scores with time and no significant difference between them. In the BID-group post-ACTH cortisol concentrations went below 250 nmol/l sooner and in a higher proportion of dogs than in the SID-group. Twice-daily administration of trilostane also achieved a faster and more effective control for comparable daily doses. A higher individual tolerability (based on clinical scores) was found in the SID-group but there were no supporting laboratory findings. No dogs developed serious side-effects. CONCLUSION: This study reveals only small practical differences between once and twice daily trilostane administrations in treating hyperadrenocorticism. And the overall benefits of twice daily dosing have to be considered against the effect on the owners and their compliance with treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23242222/