A Controlled Cortical Impact Preclinical Model of Traumatic Brain Injury.

Abstract

Over the past three decades, attempts at understanding the multifaceted mechanisms underlying the pathophysiology of traumatic brain injury (TBI) have seen the development of numerous animal models to investigate changes in molecular and cellular pathways and neurobehavioral outcomes. Until now, controlled cortical impact (CCI) represents the most frequently used mechanical model to induce TBI, given its accuracy, easy of control, and, most importantly, its ability to produce brain injuries similar to those seen in humans. The CCI model is based on the use of an impact system that delivers a physical impact to the exposed dura of an animal. This chapter will describe in detail the electromagnetic CCI model of TBI in mice.