Peer-reviewed veterinary case report
A decade of research into classical swine fever marker vaccine CP7_E2alf (SuvaxynCSF Marker): a review of vaccine properties.
- Journal:
- Veterinary research
- Year:
- 2017
- Authors:
- Blome, Sandra et al.
- Affiliation:
- Institute of Diagnostic Virology · Germany
Abstract
Due to its impact on animal health and pig industry, classical swine fever (CSF) is still one of the most important viral diseases of pigs. To control the disease, safe and highly efficacious live attenuated vaccines exist for decades. However, until recently, the available live vaccines did not allow a serological marker concept that is essentially important to circumvent long-term trade restrictions. In 2014, a new live attenuated marker vaccine, SuvaxynCSF Marker (Zoetis), was licensed by the European Medicines Agency. This vaccine is based on pestivirus chimera "CP7_E2alf" that carries the main immunogen of CSF virus "Alfort/187", glycoprotein E2, in a bovine viral diarrhea virus type 1 backbone ("CP7"). This review summarizes the available data on design, safety, efficacy, marker diagnostics, and its possible integration into control strategies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28915927/