Peer-reviewed veterinary case report
A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.
- Journal:
- Nature neuroscience
- Year:
- 2009
- Authors:
- Miller, Bradley R et al.
- Affiliation:
- Department of Developmental Biology · United States
- Species:
- rodent
Abstract
Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase (DLK) [corrected to add (DLK) abbreviation] promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19287387/