Peer-reviewed veterinary case report
Dual-strain cat calicivirus vaccine cuts severe disease signs
By Huang, Chengjin et al.·Published in Journal of Feline Medicine and Surgery·2010·Fort Dodge Animal Health, 9225 Indian Creek Parkway, Suite 400, Overland Park, KS 66213, USA, United States·View original on Crossref →
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Original publication title: A dual-strain feline calicivirus vaccine stimulates broader cross-neutralization antibodies than a single-strain vaccine and lessens clinical signs in vaccinated cats when challenged with a homologous feline calicivirus strain associated with virulent systemic disease
- Species:
- cat
Plain-English summary
A group of cats was vaccinated with a new dual-strain feline calicivirus (FCV) vaccine to see if it would help protect them against a serious form of the virus that can cause severe illness. After being exposed to this dangerous strain, the vaccinated cats showed fewer symptoms compared to those that weren't vaccinated. This vaccine not only helped reduce the severity of the disease but also stimulated the immune system to better fight off different strains of the virus. Overall, the dual-strain vaccine proved to be more effective than the traditional single-strain option.
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Abstract
Feline calicivirus (FCV) causes an array of clinical disease in cats. Traditionally this disease has been associated with respiratory disease, limping, or chronic stomatitis. Within the last 10 years, virulent systemic feline calicivirus (VS-FCV) has been recognized which causes additional clinical signs and has a higher fatality rate. A dual-strain FCV vaccine containing a strain of FCV associated with traditional respiratory disease and a VS-FCV strain stimulates serum cross-neutralization antibodies when tested against field strains from Europe and VS-FCV strains from USA. Following challenge with a homologous VS-FCV strain, vaccinated cats had significantly reduced clinical signs.
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Search related cases →Original publication on Crossref: https://doi.org/10.1016/j.jfms.2009.08.006