Peer-reviewed veterinary case report
Muscle invasion linked to fibromyxoid stroma in dog bladder cancer
By de Brot, S et al.·Published in Journal of comparative pathology·2019·School of Veterinary Medicine and Science, United Kingdom·View original on PubMed →
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Original publication title: A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma.
- Species:
- dog
Plain-English summary
A 10-year-old neutered female Scottish Terrier was diagnosed with urothelial carcinoma, a common type of bladder cancer in dogs. The tumor showed a fibromyxoid stroma, which is a specific tissue type that was linked to the cancer invading the muscle wall of the bladder, indicating a more severe case. Inflammation and mild necrosis were also present, which can affect the prognosis. Unfortunately, this type of cancer can be aggressive, and the presence of fibromyxoid stroma suggests a poorer outcome for the dog. Treatment options typically include surgery and chemotherapy, but the prognosis remains guarded.
People also search for: Scottish Terrier bladder cancer · dog urothelial carcinoma treatment · canine cancer prognosis
Abstract
Canine urothelial carcinoma (UC) is the most common type of cancer of the lower urinary tract and tends to affect elderly neutered female dogs, with a high predisposition for Scottish terriers. Tumour stroma, inflammation and necrosis are poorly characterized in canine UC and their role as prognostic factors is unknown. The aims of this study were to (1) assess histologically 381 canine UCs, with emphasis on myxoid tumour stroma, inflammation and necrosis and (2) assess possible associations between these features and the available epidemiological data as well as bladder wall muscle invasion. In 103 of 381 (27%) cases, the stroma was mixed collagenous and myxoid (fibromyxoid), which was strongly associated with invasive growth of muscle (P <0.0001). Peritumoural and intratumoural inflammation was present in 308 of 345 (89%) and 287 of 381 (75%) cases, respectively, and was mostly mild and lymphoplasmacytic. One hundred and fifteen of the 381 (30%) cases showed a variable eosinophilic inflammation and 58 of 381 (15%) presented with formations of one or several lymphoid follicles. Twenty-four percent (91 of 381) of cases had tumour necrosis, which was typically mild. In 83 of 91 (91%) cases, the necrosis was comedo-like. Moderate to severe tumour necrosis was associated with the presence of moderate to predominant fibromyxoid tumour stroma (P <0.02). The results of this study indicate that fibromyxoid stroma is common in canine UC and is a strong indicator for invasive growth of muscle, which is consistent with a poor prognosis. Based on histomorphology, tumour necrosis in canine UC is best described as comedonecrosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31159949/