Peer-reviewed veterinary case report
Oral fluralaner treats generalized demodicosis in dogs in Thailand
By Duangkaew, Lerpen et al.·Published in Veterinary dermatology·2018·Veterinary Teaching Hospital·View original on PubMed →
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Original publication title: A field trial in Thailand of the efficacy of oral fluralaner for the treatment of dogs with generalized demodicosis.
- Species:
- dog
Plain-English summary
A group of dogs in Thailand with generalized demodicosis, a skin condition caused by mites, were treated with an oral medication called fluralaner. The treatment was effective, with many dogs showing improvement and reaching a "parasitological cure" after two to four months. This means that after treatment, their skin scrapings showed no signs of mites. Importantly, no side effects were noted from the medication.
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Abstract
BACKGROUND: Generalized demodicosis in dogs can be challenging to manage, especially in adult-onset cases. HYPOTHESIS/OBJECTIVES: This study evaluated the efficacy of oral fluralaner at the dose of 25-50 mg/kg for the treatment of canine generalized demodicosis. ANIMALS: Client-owned dogs from Bangkok, Thailand, diagnosed with generalized demodicosis according to published criteria. METHODS: Deep skin scrapings were performed at three to five affected areas to evaluate numbers of mites. Repeat examinations were performed monthly until parasitological cure; dogs were then followed up for two to 12 months. Parasitological cure was defined as two negative skin scrapings achieved one month apart. RESULTS: One hundred and fifteen dogs were included in the study, 73 with adult-onset demodicosis and 42 with juvenile-onset demodicosis. Twenty one dogs were lost to follow-up and 27 had one negative skin scraping but did not return. Sixty seven dogs (21 with juvenile-onset and 46 with adult-onset disease) reached parasitological cure, which occurred after two, three and four months in 63%, 85% and 100% (respectively) of dogs with adult-onset demodicosis, cumulatively, and after two and three months in 81% and 100% of dogs with juvenile-onset demodicosis. Underlying causes associated with adult-onset demodicosis included atopic dermatitis, neoplasia, metabolic diseases and idiopathy. No adverse effects of fluralaner were observed in any of the dogs. CONCLUSION: Fluralaner given at the label dose for flea and tick prevention is effective for the treatment of canine generalized demodicosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29424108/