Peer-reviewed veterinary case report
Single joint injection with blood cell secretome and steroid helps
By Alves, J C et al.·Published in BMC veterinary research·2022·Divisã·View original on PubMed →
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Original publication title: A first report on the efficacy of a single intra-articular administration of blood cell secretome, triamcinolone acetonide, and the combination of both in dogs with osteoarthritis.
- Species:
- dog
Plain-English summary
A group of 15 dogs with hip osteoarthritis, averaging 9 years old, received either a treatment of blood cell secretome, triamcinolone (a common steroid), or a combination of both to help manage their pain. Over several months, those treated with the combination showed the most significant improvement in pain levels and overall mobility compared to the other groups. The dogs experienced better quality of life and less pain after receiving the combined treatment. This suggests that using both therapies together may be more effective for dogs suffering from hip osteoarthritis.
People also search for: dog hip osteoarthritis treatment · blood cell secretome for dogs · triamcinolone for dog arthritis
Abstract
BACKGROUND: Osteoarthritis represents a significant welfare problem for many dogs, with limited therapeutic options other than palliative pain control. To evaluate the effect of the intra-articular administration of blood cell secretome and triamcinolone, 15 dogs with bilateral hip osteoarthritis were randomly assigned to a blood cell secretome (BCSG, n = 5), triamcinolone (TG) or their combination group (BCS + TG, n = 5). BCSG received a single intra-articular administration of 3 ml of blood cell secretome, TG 0.5 ml of triamcinolone acetonide 40 mg/ml, and BCS + TG received the combined products. The volume to administrate was corrected to 3.5 ml with saline. On days 0, 8, 15, 30, 60, 90, 120, 150, and 180, a copy of the Canine Brief Pain Inventory (divided into pain interference score-PIS and Pain Severity Score-PSS), Liverpool Osteoarthritis in Dogs (LOAD), Hudson Visual Analogue Scale (HVAS), and Canine Orthopedic Index (COI, divided into function, gait, stiffness, and quality of life) was completed. Results were analyzed with the Kruskal-Wallis test and the Kaplan-Meier estimators were conducted and compared with the Log Rank test, p < 0.05. RESULTS: Animals in the sample had a mean age of 9.0 ± 2.9 years and a bodyweight of 28.8 ± 4.1 kg. Hips were classified as moderate (8) and severe (7) osteoarthritis. No differences were found between groups at T0 regarding considered evaluations. Significant differences were observed between groups in pain scores from + 8d- + 150d, with BCS + TG exhibiting better results. The same was observed for HVAS and LOAD, from + 8d- + 120d. Improvements were also observed in several dimensions of the COI. Kaplan-Meier estimators showed that BCS + TG produced longer periods with better results, followed by BCSG and TG. CONCLUSION: The intra-articular administration of blood cell secretome improved the clinical signs and scores of several clinical metrology instruments in dogs with hip OA, particularly when combined with triamcinolone. Further studies are required.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35962448/