Peer-reviewed veterinary case report
Genetic region on chromosome 12 linked to claw loss in Gordon
By Dahlgren, S et al.·Published in Animal genetics·2016·Department of Basic Sciences and Aquatic Medicine·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: A genome-wide association study identifies a region strongly associated with symmetrical onychomadesis on chromosome 12 in dogs.
- Species:
- dog
Plain-English summary
A group of Gordon Setters was studied for a condition called symmetrical onychomadesis, which causes them to lose their claws periodically. Researchers found a specific area on chromosome 12 that seems to be linked to this issue, and they also noted similar findings in English Setters. This genetic information could help breeders select dogs that are less likely to develop this claw loss problem in the future. While the study didn't find specific markers in certain genes, it highlighted the importance of genetics in understanding this condition.
People also search for: why is my dog losing claws · Gordon Setter claw loss · symmetrical onychomadesis treatment · English Setter health issues · dog genetic conditions
Abstract
Symmetrical onychomadesis causes periodic loss of claws in otherwise healthy dogs. Genome-wide association analysis in 225 Gordon Setters identified a single region associated with symmetrical onychomadesis on chromosome 12 (spanning about 3.3 mb). A meta-analysis including also English Setters indicated that this genomic region predisposes for symmetrical onychomadesis in English Setters as well. The associated region spans most of the major histocompatibility complex and nearly 1 Mb downstream. Like many other autoimmune diseases, associations of symmetrical onychomadesis with DLA class II alleles have been reported. In this study, no associated markers were revealed within any of the DLA-DRB1, -DQA1 or -DQB1 genes, and the odds for symmetrical onychomadesis in the Gordon Setters were much higher, carrying significant single nucleotide polymorphisms compared to the odds of any of the recorded DLA-DRB1/DQA1/DQB1 haplotypes. We noticed that some of the associated DLA haplotypes were different between the English Setters and the Gordon Setters. Interestingly, associated SNP chip markers showed a more consistent pattern of allelic variants related to cases or controls regardless of breed. In conclusion, the associated genetic markers identified in this study hold the potential to aid in selection of breeding animals to reduce the frequency of symmetrical onychomadesis in the dog.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27629549/