Peer-reviewed veterinary case report
Hereditary skin thickening and birth defects in Rottweiler dogs
By Lewis et al.·Published in Veterinary dermatology·1998·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: A hereditary disorder of cornification and multiple congenital defects in five Rottweiler dogs.
- Species:
- dog
Plain-English summary
Five female Rottweiler dogs were found to have a hereditary skin disorder that caused thickened, discolored patches on their skin. In addition to the skin issues, three of the dogs also had other congenital defects. Treatments with zinc, vitamin A, and calcitriol did not improve their skin condition. This disorder is similar to certain human skin conditions and appears to be inherited in a way that primarily affects females. Unfortunately, the dogs did not show any improvement despite treatment efforts.
People also search for: Rottweiler skin problems · dog hereditary skin disorder · thickened skin patches in dogs · vitamin A for dog skin issues · congenital defects in Rottweilers
Abstract
The clinical, biochemical, histological, or ultrastructural abnormalities of five related female Rottweiler dogs with a hereditary disorder of cornification are reported. Three of the five dogs also had multiple noncutaneous congenital defects. Cutaneous abnormalities included generalized, hyperkeratotic, variably pigmented plaques, which in one dog were distributed along Blaschko's lines. Moderate to severe parakeratosis involving the follicular infundibula and ostia and focal orthokeratosis with variable vacuolation of spinous cells was observed on histopathologic examination of all skin specimens. Supplementation with oral zinc in two dogs and vitamin A alcohol and calcitriol in one dog did not result in clinical or histological improvement of the hyperkeratotic lesions. This disorder of cornification in dogs is similar to human disorders of cornification that follow the lines of Blaschko. Blaschko's lines follow a V-shape over the spine, an S-shape on the abdomen, and an axial distribution on the limbs. No related male dogs were affected, suggesting an X-linked dominant mode of inheritance. Many features of this hereditary DOC correspond to the human condition CHILD syndrome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34644958/