Peer-reviewed veterinary case report
A lipid mediator controls neutrophil recruitment in acute lung injury--should we really be surprised?
- Journal:
- Critical care (London, England)
- Year:
- 2012
- Authors:
- Zasłona, Zbigniew & Peters-Golden, Marc
Abstract
New therapeutic approaches are sorely needed for acute lung injury. Neutrophil recruitment is a pathological hallmark of this syndrome, and is mainly regulated by CXC chemokine receptor 2 and its ligand CXC ligand 1. Rossaint and colleagues have described a new mechanism for regulation of this axis by 12/15-lipoxygenase products. This work opens the door for new therapeutic approaches and highlights the crucial interplay between lipid mediators and chemokines, a time-honored but often-ignored concept.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23102473/