Peer-reviewed veterinary case report
MRI grading system to guide pituitary surgery in dogs with Cushing's
By Sato, A et al.·Published in The Journal of small animal practice·2016·Department of Veterinary Science, Japan·View original on PubMed →
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Original publication title: A magnetic resonance imaging-based classification system for indication of trans-sphenoidal hypophysectomy in canine pituitary-dependent hypercortisolism.
- Species:
- dog
Plain-English summary
A group of dogs with pituitary-dependent hypercortisolism (a condition causing excessive cortisol) underwent magnetic resonance imaging (MRI) to determine if they were candidates for surgery. Out of 37 dogs, 33 had surgery, and most of those with lower-grade tumors (Grades 1 to 3) had successful outcomes, with 29 dogs going into remission. However, dogs with more advanced tumors (Grades 4 and 5) did not respond well to surgery and required other treatments. Overall, dogs with lower-grade tumors had a good chance of recovery after surgery.
People also search for: dog Cushing's disease treatment · pituitary tumor surgery in dogs · dog hyperadrenocorticism prognosis
Abstract
OBJECTIVES: The objectives of this study were to establish a magnetic resonance imaging-based classification system for canine hyperadrenocorticism according to pituitary gland extension, determine indications for trans-sphenoidal hypophysectomy, and clarify the prognosis for each disease grade. METHODS: A 5-point classification system (Grades 1 to 5) was developed based on tumour extension in dorsal and cranio-caudal directions. Cases were then classified as Type A: no arterial circle of Willis or cavernous sinus involvement and Type B: cases in which these blood vessels were involved. RESULTS: Medical records and magnetic resonance imaging data of 37 cases with hyperadrenocorticism were reviewed. Thirty-three cases underwent surgery; 4 Grade 5 cases did not have appropriate indications for surgery, and other therapies were used. Complete resection was achieved for 3, 3, 22 and 1 Grade 1A, 2A, 3A and 3B cases, respectively. Resection was incomplete in 1, 1 and 2 Grade 3A, 3B and 4B cases, respectively. Remission was achieved in 29 cases. Recurrence occurred in 4 cases, all of which were classified as Grade 3. CLINICAL SIGNIFICANCE: Dogs with Type A, Grade 1 to 3 hyperadrenocorticism had a good prognosis following trans-sphenoidal hypophysectomy. Grade 3B, 4 and 5 cases may not be suitable for this surgery.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27101315/