Peer-reviewed veterinary case report
A marine microbiome antifungal targets urgent-threat drug-resistant fungi.
- Journal:
- Science (New York, N.Y.)
- Year:
- 2020
- Authors:
- Zhang, Fan et al.
- Affiliation:
- University of Wisconsin-Madison · United States
Abstract
New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistantLeveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug-resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33214279/