A metabolome-driven deep exploration into Moringa's medicinal efficacy.

Abstract

Moringa oleifera Lam. (Moringa) is used to make accepted herbal medicines. Although many studies have highlighted the potential clinical applications of Moringa, its use remains uncertain. Therefore, in this research, a novel integrated strategy based on a signature metabolome was applied to drive the precise exploration of Moringa, which was verified in a rat model. The clinical applications predicted by the signature metabolic profile of Moringa was subsequently verified in disease models. Furthermore, after verification by quantitative methods, we used a biomarker, FA 18:3/FA 20:2, for earlier detection of alcoholic fatty acid disease. This study demonstrated a convenient strategy for the accurate exploration of Moringa for the first time and verified that metabonomics-based biomarkers can indeed be used for the early detection of new indicators.