Peer-reviewed veterinary case report
Dog with stomach tumor causing vomiting and weight loss
By Atherton, Matthew J et al.Ā·Published in Veterinary clinical pathologyĀ·2017Ā·Department of Pathology and Molecular Medicine, CanadaĀ·View original on PubMed ā
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Original publication title: A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old crossbred dog was brought to the vet after experiencing vomiting blood, black stools, loss of appetite, and tiredness for six weeks. The vet found a mass in the stomach and swollen lymph nodes, and tests showed a type of cancer called extramedullary plasmacytoma (EMP). The dog responded well to chemotherapy initially, but sadly, it was euthanized eight months later due to the aggressive nature of the cancer. A postmortem exam confirmed the diagnosis.
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Abstract
A 10-year-old crossbred dog was presented with a 6-week history of hematemesis, melena, anorexia, and lethargy. Clinical evaluation revealed a gastric mass with a regional lymphadenomegaly as well as a monoclonal gammopathy manifesting as hyperglobulinemia. Cytologic and histopathologic analyses were consistent with a round cell neoplasm; neoplastic cells showed nuclear immunoreactivity for MUM1 and diffuse cytoplasmic reactivity for CD3. Polymerase chain reactions performed on fixed and fresh tissue identified a clonal rearrangement with an IgH primer set. An extramedullary plasmacytoma (EMP) was confirmed by cellular morphology and molecular diagnostics. Following an objective response to chemotherapy, the dog was euthanized 8 months after diagnosis, and a postmortem examination confirmed the clinical findings. This is the first reported case of a monoclonal gammopathy secondary to a gastric EMP coupled with aberrant expression of CD3 in an aggressive plasmacytic tumor, and highlights the utility of molecular diagnostics for classifying atypical hemolymphoid neoplasms.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28582596/