Peer-reviewed veterinary case report
Genetic mutation linked to deafness and balance issues in Doberman
By Webb, Aubrey A et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2019·Department of Clinical Neurosciences, United States·View original on PubMed →
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Original publication title: A missense mutation in MYO7A is associated with bilateral deafness and vestibular dysfunction in the Doberman pinscher breed.
- Species:
- dog
Plain-English summary
A Doberman pinscher was found to have bilateral deafness (he couldn't hear from either ear) along with balance issues, which means he had trouble standing or walking straight. Researchers discovered a specific genetic mutation in the MYO7A gene that is linked to these problems. This mutation does not affect the dog's eyesight, which is different from how it works in humans. With DNA testing available for this mutation, breeders can better manage and reduce the chances of this genetic issue in future puppies.
People also search for: Doberman pinscher deafness · dog balance problems · MYO7A gene testing for dogs · genetic deafness in dogs · how to help a deaf dog
Abstract
Bilateral deafness with concurrent vestibular dysfunction was first reported in the Doberman pinscher in 1980. Here, we identify a coding mutation in the MYO7A gene that is perfectly associated with the disorder. The lack of visual deficits in affected dogs suggests that, like rodents but unlike humans, MYO7A is not required for retinal function. DNA testing of the mutation will enable dog breeders to manage the incidence of this genetic defect.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31097876/