Peer-reviewed veterinary case report
A model of anxious depression: persistence of behavioral pathology.
- Journal:
- Neuroscience and behavioral physiology
- Year:
- 2005
- Authors:
- Avgustinovich, D F et al.
- Affiliation:
- Institute of Cytology and Genetics
- Species:
- rodent
Abstract
Chronic psychoemotional stress induced by negative experience of social defeats in intermale confrontations over a period of 30 days was found to lead to the development of anxious-depressive symptomatology in male mice. Cessation of the psychopathogenic conditions and placing of depressed animals in comfortable conditions for 1-2 weeks with females did not lift the pathological state. Individuals continued to show marked anxiety, a behavioral deficit, decreased communicativeness, and a high level of depressivity, as revealed by a variety of behavioral tests. Persistence of the resulting psychoemotional disturbance in these animals is evidence for the development and persistence of the behavioral pathology requiring drug treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16270173/