Peer-reviewed veterinary case report
A modified rat model for hepatocellular carcinoma.
- Journal:
- Hepatobiliary & pancreatic diseases international : HBPD INT
- Year:
- 2004
- Authors:
- Yang, Fu-Chun et al.
- Affiliation:
- Department of Hepatobiliary Pancreatic Surgery and Liver Transplantation Center · China
- Species:
- rodent
Abstract
BACKGROUND: Rat hepatocellular carcinoma (HCC) model which has a high analogy to clinical liver cancer is of great value in understanding the pathogenesis and evolution of liver cancer, in searching effective anti-cancer treatments (drug, hepatectomy and liver transplantation), and designing cancer prevention strategies. In this study we established a modified rat model of hepatocellular carcinoma to enhance rats' physique and surgical endurance. METHODS: Wistar rats were fed with diethylnitrosamine (DENA) by three methods for evaluation of general conditions for 130 days: Doppler ultrasonographic measurement, laparotomy and histopathological examination. RESULTS: No rat died in control group (group A) and modified DENA-induction-HCC group(group C), but 6 deaths in classical DENA-induction-HCC group (group B) (survival rate 80%). All survived rats in groups B and C developed diffusive hepatocellular carcinoma and liver cirrhosis. General appearance of rats in the group C was better than that in the group B. CONCLUSION: With good general conditions for surgery, the modified rat model for hepatocellular carcinoma has a high carcinogenic rate and a high survival rate.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15567750/