Peer-reviewed veterinary case report
Intravitreal membranes linked to eye bleeding in dogs explained
By Zeiss, Caroline J & Dubielzig, Richard R·Published in Veterinary ophthalmology·2004·Yale School of Medicine, United States·View original on PubMed →
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Original publication title: A morphologic study of intravitreal membranes associated with intraocular hemorrhage in the dog.
- Species:
- dog
Plain-English summary
A 4 to 11-year-old Labrador Retriever or Labrador-cross and a Springer Spaniel were found to have membranes inside their eyes due to bleeding. These membranes were linked to conditions like glaucoma and other eye problems, which can cause new blood vessels to form and lead to further bleeding. The study found that the membranes varied in how organized they were, but they were not made of muscle tissue and did not have their own blood supply. Understanding these membranes can help veterinarians treat the underlying issues causing the bleeding and protect the dog's vision.
People also search for: dog eye bleeding treatment · Labrador Retriever glaucoma symptoms · Springer Spaniel eye problems
Abstract
Abstract We aimed to characterize intravitreal membranes in dogs and determine, if possible, associated predisposing conditions. Five globes in which intravitreal membranes were identified were evaluated. These originated from four Labrador Retrievers or Labrador-cross dogs and a Springer Spaniel. The ages of the dogs ranged from 4 to 11 years. Standard histology and immunohistochemical procedures for factor VIII-related antigen, smooth muscle actin (SMA), vimentin and glial fibrillary acidic protein (GFAP) were performed. Intravitreal membranes varied from loosely to highly organized. The extent of organization corresponded with increasing immunoreactivity for vimentin and GFAP, indicating their predominantly glial origin. They were never immunopositive for smooth muscle actin, nor were they vascularized. In all cases, they were associated with intravitreal hemorrhage. Additional common findings included epiretinal membranes, retinal neovascularization, preiridal fibrovascular membranes and glaucoma. Intravitreal membranes may be a sequelae of intravitreal hemorrhage. This in turn, may arise from new vessels associated with epiretinal or preiridial membranes, or hemorrhage associated with optic disc cupping or retinal neovascularization. All of these phenomena may accompany glaucoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15200620/