Peer-reviewed veterinary case report
A Mosquito AgTRIO Monoclonal Antibody Reduces EarlyInfection of Mice.
- Journal:
- Infection and immunity
- Year:
- 2022
- Authors:
- Chuang, Yu-Min et al.
- Affiliation:
- Department of Internal Medicine · United States
- Species:
- rodent
Abstract
Malaria begins when an infected mosquito injects saliva containingsporozoites into the skin of a vertebrate host. Passive immunization of mice with antiserum against the Anopheles gambiae mosquito saliva protein TRIO (AgTRIO) offers significant protection againstinfection of mice. Furthermore, passive transfer of both AgTRIO antiserum and an anti-circumsporozoite protein monoclonal antibody provides synergistic protection. In this study, we generated monoclonal antibodies against AgTRIO to delineate the regions of AgTRIO associated with protective immunity. Monoclonal antibody 13F-1 markedly reducedinfection in mice and recognized a region (VDDLMAKFN) in the carboxyl terminus of AgTRIO. 13F-1 is an IgG2a isotype monoclonal antibody, and the Fc region is required for protection. These data will aid in the generation of future malaria vaccines that may include both pathogen and vector antigens.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34724388/